C U R R I C U L U M V I T A E
| Personal:
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| Name: | Philipp Bucher. |
| date of birth: | August 6, 1955 (Zürich, Switzerland). |
| Marital status: | Married/separated, three children |
| Citizenship: | Swiss |
| Professional address: |
Swiss Institute for Experimental Cancer Research (ISREC)
and Swiss Institute of Bioinformatics (SIB) Ch. des boveresses 155 CH-1066 Epalinges s/Lausanne Switzerland Phone: +41-21-692-5892, Fax: +41-21-692-5945, Email: Philipp.Bucher@isrec.unil.ch |
| Education/Experience: | |
| 1962 - 1968 | Primary school in Zürich. |
| 1968 - 1974 | High school in Zürich (Literargymnasium Rämibuhl). Degree: Federal matriculation exam type A. |
| 1974 - 1980 | Studies in molecular biology at University of Zürich. Degree: Diploma in molecular biology. Title of diploma thesis: "Sequence analyses of histone genes in the sea urchin species Psammechinus miliaris; the complete sequence of an H1 gene expressed at early stages of embryonic development." (Advisor: Dr. M.L. Birnstiel). |
| 1981 - 1982 | Beginning of researches in computer applications to nucleic acid sequences with Dr. M.L. Birnstiel at University of Zürich. Development of computer programs for comparative DNA sequence analysis. Joint work with Dr. T. Koller on left-handed DNA. |
| 1983 | Research on plant histone genes with Dr. L. Hirth at IBMC Strasbourg, France. |
| 1984 | System analyst at the computer center of ALUSUISSE, Zürich. Redesign and conversion of software packages. |
| 1985 - 1989 | Ph.D. with Dr. E.N. Trifonov at the Weizmann Institute of Science, Rehovot, Israel. Title of Ph.D. thesis: "Comparative analysis of eukaryotic promoters and development of computer algorithms to characterize nucleotide sequence patterns positionally correlated with a biological site". |
| 1988 | Short stay at EMBL, Heidelberg, Germany. Preparation of first EPD (Eukaryotic Promoter Database) release with Drs. Graham Cameron and David Hazledine. |
| 1989 - 1991 | Postdoctoral research position with Dr. S. Karlin at Stanford University. Statistical analyses of protein sequences. Continuation of work on EPD and comparative sequence analysis of eukaryotic promoters. |
| 1991 | Short stay at NCBI, Bethesda, USA. Conversion of EPD into ASN.1 format with Dr. James Ostell. |
| 1991 - 1995 |
Postdoctoral research position at ISREC, Epalinges s/Lausanne.
Improvement of the sequence profile methodology.
Design and introduction of a new profile structure and format
for the PROSITE databank of protein motifs.
Various collaborations with experimental groups.
Maintenance of EPD.
Teaching: Practical courses in computer-aided molecular sequence analysis. |
| 1995 - 1999 |
Associate scientist at ISREC.
Further improvements of the generalised profile technique.
Development of the pftools software package.
Discovery of several new protein domains.
Adaptation of the profile technique to in silico
gene discovery applications.
Reorganisation and introduction of a new format
of EPD as part of an EC-funded international collaboration
(TRADAT project).
Various collaborations with experimental groups.
Teaching: Practical and theoretical courses in computer-aided molecular sequence analysis. Advanced courses in genomics and genome sequence analysis. |
| Current Position: | |
| 2000 - |
Senier scientist at ISREC.
Research on conserved protein domains and gene regulatory regions.
Development of new algorithms and software for comparative genomics
and protein sequence analysis. Characterization of transcription
factor binding sites by experiental and computational methods.
Maintenance of the promoter and gene expression databases
EPD (
http://www.epd.isb-sib.ch/) and
CleanEx (
http://www.cleanex.isb-sib.ch/).
Development of the Signal Search Analysis (SSA) server
(
http://www.isrec.isb-sib.ch/ssa/).
Teaching: Module "Sequence Analysis" of the joint "Masters in Bioinformatics" program of the Universities of Lausanne and Geneva. Additional affiliation: Group leader at the Swiss Institute of Bioinformatics (SIB). |
| Research grants: | |
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