Areas of Research
Statistical methods have come to play a pivotal role in bioinformatics. My work focuses on statistical and bioinformatics method and software development in molecular biology, especially in genetics and genomics. My research interests are in the following areas:
Statistical and computational methods for molecular data analysis
- linkage mapping of complex traits in humans and experimental organisms
- genomic, proteomic and biological metadata data analysis
- sequence analysis
Comparative genetics and genomics
- human and mouse linkage analysis of complex traits
- mammalian gene expression in Huntington's disease
Computer-intensive statistical methods
- graphical exploration of high-dimensional data
- resampling methods in genomics and sequence analysis
- multiple imputation for missing genetic data
Integration of heterogeneous biological data types
- adaptation of meta-analysis methods for high-dimensional data
- Bayesian methods for molecular data integration
Active Collaborations
In addition to my own work, I am involved in a number of scientific collaborations.
Projects I am currently working on include:
Human, mouse and rat genomic studies of Huntington's disease
Collaborator: Ruth Luthi-Carter,
Laboratoire de neurogénomique fonctionnelle, EPFL
Bayesian methods for molecular data integration
Collaborator: Terry Speed, Statistics Department, UC Berkeley and WEHI, Melbourne
Comparison of microarray, PCR and digital gene expression technologies
Collaborators: Mauro Delorenzi and Eugenia Migliavacca, ISREC Bioinformatics Core Facility and Swiss Institute of Bioinformatics; and Victor Jongeneel, Ludwig Institute for Cancer Research and Swiss Institute of Bioinformatics
Methodology and software development for gene expression in large data sets
Collaborators: Li Long, Swiss Institute of Bioinformatics, VITAL-IT Project; and Francois Collin, Affymetrix
Atlas of gene expression in Arabidopsis thaliana
Collaborators: Lars Hennig, Institute of Plant Sciences, ETH Zurich;
and Mauro Delorenzi, ISREC Bioinformatics Core Facility and Swiss Institute of Bioinformatics
Computational methods for large-scale microarray quality assessment
Collaborators: Lars Hennig, Institute of Plant Sciences, ETH Zurich;
and Francois Collin, Affymetrix
Methodologies for quality assessment of Affymetrix GeneChips
Collaborators: Gareth Hughes, Lesley Jones and Angela Hodges,
Departments of Psychological Medicine and Medical Genetics,
Wales College of Medicine and School of Biosciences, Cardiff University;
and Francois Collin, Affymetrix
Statistical modeling of quantitative RT-PCR data
Collaborator: Rolf Jaggi, Department of Clinical Research, University of Bern
Susceptibility genes for osteoarthritis of the hip
Collaborators: Alex Odermatt and Evelyne Maurer,
Division of Nephrology and Hypertension, Department of Clinical Research, University of Bern
