Immune Response Simulation Server

TCR Clonal Selection Experiment

(Philipp Bucher & Janet L. Maryanski)
Biological background: see
    Attuil V, Bucher P, Rossi M, Mutin M, Maryanski JL (2000), Comparative T cell receptor repertoire selection by antigen after adoptive transfer: A glimpse at an antigen-specific preimmune repertoire. Proc. Natl. Acad. Sci. USA 97, 8473-8478.
Description of the Simulation Process

Input Form
Input repertoire: Number of donor mice:
Number of selectable cells per donor mouse:
Type of repertoire:
      Equal clone size - number of clones:
      Unequal clone size - exponental decay constant:
Selection process: Number of recipient mice:
Number of selected cells:
Selection mode:
      Uniform
      Non-uniform - maximal burst size ratio
Number of sequences analysed:
Number of selection experiments:
Output options: Input data summary
Donor repertoire characteristics
Selected repertoire characteristics
Summary statistics
     
Questions and comments regarding the simulation process and bug reports should be sent to: Philipp Bucher;
Questions and comments regarding the biological background should be addressed to: Janet L. Maryanski;