The Rhodanese homology domain

A sequence motif present in rhodanese (N- and C-terminal), in the Cdc25 phosphatase and other phosphatases and transferases.

This page contains supplementary material to the paper
Hofmann K., Bucher P., and Kajava, A.V.,
A model of Cdc25 Phosphatase Catalytic Domain and Cdk-Interaction Surface Based on the Presence of a Rhodanese Homology domain.
J. Mol. Biol. 282:195-208 (1998)

Short description

A homology region that forms the catalytic domain in various phosphatases and transferases (including Cdc25, rhodanese C-terminus) and also occurs in the non-catalytic domain of other enzymes (including MAPK-phosphatases, rhodanese N-terminus, Ubiquitin hydrolases). Protein families with Rhodanese homology domains include:

Rhodanese and related sulfur transferases (catalytic and non-catalytic domains)
Cdc25 family of protein dual specificity phosphatases
The MKP1/PAC1 family of MAP-kinase phosphatases
The Pyp1/Pyp2 family of MAP-kinase phosphatases
Several ubiquitin hydrolases (yeast UBP4,5,7; human UBPY)
Various stress response proteins (heat shock, phage shock, cold shock) from all phyla

PROSITE

The Rhodanese homology domain will be included in PROSITE under the accession numbers PS550206 for the data entry, and PDOC50206 for the documentation entry. The alignment used for construction of the profile is available in MSF format. There is also an updated list of database sequences containing Rhodanese domains.

Cdc25 model

The paper describes a molecular model of the rhodanese homology domain in Cdc25. The coordinates for the model are available here.

Figures

A Version of the alignment figure (figure 1 in the paper) in MS-WORD format can be downloaded here.

Note: You can check your sequence for the occurence of this and other domains by using the ProfileScan server.

Go back to the protein domains page or to the ISREC-bioinformatics home page