The PCI domain

A sequence motif found in subunits of multi-protein complexes, including the 26S proteasome

This page is based on the manuscript
Hofmann K. and Bucher P. (1998),
PCI and MPN-domains: Scaffold for multi-protein complexes or proteasome regulators?
(submitted for publication)

Short description

A homology domain of unclear function, occuring in the C-terminal region of several regulatory components of the 26S proteasome, as well as in other proteins [1]. Apparently, all of the characterized proteins containing PCI domains are parts of larger multi-protein complexes. The PCI domain frequently occurs in the same protein complexes as the MPN domain. Proteins with PCI domains include:

Budding yeast proteasome regulatory components Sun2, Rpn4, Rpn5, Rpn6, Rpn8
Mammalian proteasome regulatory components p55, p58 and p44.5
Budding yeast Rpg1 and Nip1, subunits of the translation initiation factor 3 complex
Mammalian p110 and INT6, subunits of the mammalian translation intitiation factor 3 complex
Arabidopsis COP9 and FUS6/COP11, components of the plant COP9-complex, involved in light signaling
Mammalian G-protein pathway suppressor GPS1
Subunits of the "signalosome" and of a multi-protein complex phosphorylated by Src.
Budding yeast ORF Yil071c
Several uncharacterized ORFs from plant, nematodes and mammals.

Also available is a more detailed description of the PCI domain and the relevant protein families.

PROSITE

The PCI domain will be included in PROSITE under the accession numbers PS550250 for the data entry, and PDOC50250 for the documentation entry. The alignment used for construction of the profile is available in MSF format. There is also an updated list of database sequences containing PCI domains.

Domain cartoons

not yet available

Alignment of representative sequences

[gif] [Postscript]

Note: You can check your sequence for the occurence of this and other domains by using the ProfileScan server.

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