The MPN domain
A sequence motif found in subunits of multi-protein complexes, including
the 26S proteasome
This page is based on the manuscript
Hofmann K. and Bucher P. (1998),
PCI and MPN-domains: Scaffold for multi-protein complexes or proteasome
regulators?
(submitted for publication)
Short description
A homology domain of unclear function, occuring in the N-terminal region
of several regulatory components of the 26S proteasome, as well as in other
proteins. Apparently, all of the characterized proteins containing MPN
domains are parts of larger multi-protein complexes. The MPN domain
frequently occurs in the same protein complexes as the PCI
domain. Protein families with MPN domains include:
-
yeast 26S-proteasome regulatory component Mpr1
-
yeast 26S-proteasome regulatory component Rpn7
-
yeast ORF Ydl216c
-
S.pombe Pad1, positive regulator of transcription factor Pap1, probably
proteasome component
-
Mammalin POH1, a Pad1 homologue and probably a proteasome component
-
Human C6.1a, a gene of unknown function in Xq28 translocation region
-
Mammalian proteasome regulatory subunit p40 (MOV34)
-
Human translation initiation factor 3 47 kDa subunit
-
Human translation initiation factor 3 40 kDa subunit
Also available is a more detailed
description of the MPN domain (and the PCI domain) and the relevant
protein families.
PROSITE
The MPN domain will be included in PROSITE under the accession numbers
PS550249
for the data entry, and PDOC50249
for the documentation entry. The alignment used for construction of the
profile is available in MSF
format. There is also an updated list of database sequences
containing MPN domains.
Domain cartoons
not yet available
Alignment of representative sequences
[gif] [Postscript]
Note: You can check your sequence for the occurence of this
and other domains by using the ProfileScan
server.
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