The FHA domain

A putative nuclear signalling domain found in protein kinases and transcription factors.

This page is based on the publication:
Hofmann K. and Bucher P. (1995), The FHA-domain: a nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem. Sci. 20:347-349

and on the poster:
Hofmann K. and Bucher P. Conserved sequence domains in cell cycle regulatory proteins presented at the joint ISREC/AACR meeting "Cancer and the Cell cycle", January 1996 in Lausanne.

Short description

The forkhead-associated (FHA) domain is a putative nuclear signalling domain found in a variety of otherwise unrelated proteins. The FHA domain comprises approximately 55 to 75 amino acids and contains three highly conserved blocks separated by divergent spacer regions.
With only one exception, all characterized proteins containing an FHA domain are thought to act in the nucleus. Several of these proteins (like DUN1 and RAD53/SAD1/MEC2/SPK1 from S.cerevisiae, or cds1 and dma1 from S.pombe) are involved in cell cycle regulation. In the plant phosphatase KAPP, a region containing the FHA domain in tis center has been shown to interact specifically with a receptor-type Ser/Thr kinase only if the kinase is autophosphorylated.

PROSITE

The FHA domain is included in PROSITE under the accession numbers PS50006 for the data entry, and PDOC50006 for the documentation entry. The alignment used for construction of the profile is available in MSF format. There is also an updated list of database sequences containing FHA domains.

Domain cartoons

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Abbreviations: FHA: FHA-domain; RF: RING-finger; FH: fork head domain; ZF: zinc finger; ATP,da: Walker1/2 ATP binding motifs; white vertical bars: predicted transmembrane regions.
Links to WWW-pages describing some of these domains can be found near the bottom of this page.

Alignment of representative sequences

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Note: You can check your sequence for the occurence of this and other domains by using the ProfileScan server.

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